Structure of PDB 8atu Chain A

Receptor sequence
>8atuA (length=2837) Species: 9606 (Homo sapiens) [Search protein sequence]
EWLVLRDGCMHCDADGLHSLSYHPALNAILAVTSRGTIKVIDGTSGATLQ
ASALSAKPGGQVKCQYISAVDKVIFVDDYAVGCRKDLNGILLLDTALQTP
VSKQDDVVQLELPVTEAQQLLSACLEKVDISSTEGYDLFITQLKDGLKNT
SHETAANHKVAKWATVTFHLPHHVLKSIASAIVNELKKINQNVAALPVAS
SVMDRLSYLLPSARPELGVGPGRSVDRSLMYSEANRRETFTSWPHVGYRW
AQPDPMAQAGFYHQPASSGDDRAMCFTCSVCLVCWEPTDEPWSEHERHSP
NCPFVKGEHTQNVPLSVTLATSPAQFPCTDGTDRISCFGSGSCPHFLAAA
TKRGKICIWDVSKLMKVHLKFEINAYDPAIVQQLILSGAMEVSLDITALS
ILQQPFPCLLAGGLLTYKSPATPLVRRTLPVLLLYSIKESDVFPKPGTLV
QCLRLPKFAEEENLCIDSITPCADGIHLLVGLRTCPVERNVSGGYLVLYK
MNYATRIVTLEEEPIKIQHIKDPQDTITSLILLPPDILDNISTLGHLVIT
TQGGYVKILDLSNFEILAKVEPPKKEGTEEQDTFVSVIYCSGTDRLCACT
KGGELHFLQIGGISGVDLLVDQPFTLEILTSLVELTRFETLTPRFSATVP
PCWVETRTWKLQTDSNSWDEHVFELVLPKACMVGHVDFKFVLNSNITNIP
QIQVTLLKNKAPGLLRLCPFLEDHKEDILCGPVWLASGLDLSGHAGMLTL
TSPKLVKGMAGGKYRSFLIHVKAVNESENLRGCDLLQEVSVTIRRFKKTS
ISKERVQRCAMLQFSEFHEKLVNTLCRKTDDGQITEHAQSLVLDTLCWLA
GVHSNGPGSSKEGNENLLSKTRKFLSDIVRVCFFEAGRSIAHKCARFLAL
CISNGKCDPCQPAFGPVLLKALLDNMSFLPAATTGGSVYWYFVLLNYVKD
EDLAGCSTACASLLTAVSRQLQDTPMEALLQTRYGLYSSPFDPVLFDLEM
SGSEIDLSDVLEGSFTSLTGLLEVEPLHFTCVSTSDGTRIERDDGLALAI
SHASHFLQPPPHQSIIIERMHSGARRFVTLDFGRPILLTDVLIPTCGDLA
SLSIDIWTLGEEVDGRRLVVATDISTHSLILHDLIPPPVCRFMKITVIGR
YGSTNARAKIPLGFYYGHTYILPWESELKNQPEIDQHLAMMVALQEDIQC
RYNLACHRLETLLQSIDLPPLNSANNAQVEEDSRVFSAYQDCIQLQLQLN
LAHNAVQRLKVALGASRKMLSETSNPEDLIQTSSTEQLRTIIRYLLDTLL
SLLHASNGHSVPAVLQSTFHAQACEELFKHLCISGTPKIRLHTGLLLVQL
CGGERWWGQFLSNVLQELYNSEQLLIFPQDRVFMLLSCIGQRSLSNSGVL
ESLLNLLDNLLSPLQVLDIPMISWVVMLVSRLLDYVATVEDEANQWSFIN
NFTLAHERCISVVQKLVLFLLSMDFTCHADLLLFVCKVLARIANATRPTI
HLCEIVNEPQLERLLLLLVGTDFNRGDISWGGAWAQYSLTCMLQDILAGE
LLSVSQALDARLEVGLEQQAELMLKMMSTLEADSILQALTNTSPLSSVPM
LNVCFNKLFSMLQVHHVQLESLLQLWLTLSLNSLYNANRIPVISLNQASI
TSFLTVLAWYPNTLLRTWCLVLHSLTLMTNMQLNQESTAHLLVSDPNLIH
VLVKFLSGTSPHGTNQHSPQVGPTATQAMQEFLTRLQVHLSSTCPQIFSE
FLLKLIHILSTERGAFQTGQGPLDAQVKLLEFTLEQNFEVVSVSTISAVI
ESVTFLVHHYITCSDKVMSRSEMTRDQLMFDLLKLVNILVQLPLSGNREY
SARVPAYVADLVLANQQIMSQILSALGLCNSSISVGDGLFTILTTLSKKA
STVHMMLQPILTYMACGTCQLSEPLLWFILRVLDTSDALKAFHDMGGVQL
ICNNMVTSTRAIVNTARSMVSTIMKFLDGIHNFAPLGTITSSSPTAQPAE
VLLQATPPHRRARSAAWSYIFLPEEAWCDLTIHLPAAVLLKEIHIQPHLA
SLATCPSSVSVEVSADGVNMLPLSTPVVTSGLTYIKIQLVKAEVASAVCL
RLHRPRDASTLGLSQIKLLGLTAFGEDQVSKTSIGWLRLLHHCLTHISDL
EGMMASAAAPTANLLQTCAALLMSPYCGMHSPNIEVVLVKIGLQSTRIGL
KLIDILLRNSDSTIDILYQLGTTQDPGTKDRIQALLKWVSDSARVAAMKT
VEYGLLMPSPSHLHCVAAILWHSYELLVEYDLPALLDQELFELLFNWSMS
LPCNMVLKKAVDSLLCSMCHVHPNYFSLLMGWMGITPLALTESHLATLAS
SSQSPEAIKQLLDSGLPSLLVRSLASFCFSHISSSESINKMPITADLVAP
ILRFLTEVGNSHIMKDWLGGSEVNPLWTALLFLLCHSGSTGLTTQQRTAI
ENATVAFFLQCISCHPNNQKLMAQVLCELFQTSPQGNISGFIRRLFLQLM
LEDEKVTMFLQSPCPLYVIQHPMYGAGHKFRTLHLPVSTTLSDVLDRVIT
VPVFHLFHKLLAGQPLPAEMTLAQLLTLLYDRKLPQGYRSIDLTVKLGSR
VISLLETCPIQSPLQVFAGMGGLALIAERLIPAHSLAAFGLFLRLPGYAE
VLLKERKHAQCLLRLVLGVLPTLPFHVLRSLFSTTPLTTDDGVLLRRMAL
EIGALHLILVCLSALSHHSPRVPRLEEEHVTCLLQVLASYINPVSSQNSN
ALPSVLLELLSQSCLIPAMSSYLRNPLYRALLELLRAIASCAAMVPLLLP
LQTSVGTLLAKMKTCVDLVPDIQKTAEIVYAATTSLR
3D structure
PDB8atu Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C328 C331 H348 C355 C275 C278 H295 C302
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0061631 ubiquitin conjugating enzyme activity
Biological Process
GO:0001890 placenta development
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0010466 negative regulation of peptidase activity
GO:0016567 protein ubiquitination
GO:0032465 regulation of cytokinesis
GO:0042127 regulation of cell population proliferation
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051301 cell division
GO:0060711 labyrinthine layer development
GO:0060712 spongiotrophoblast layer development
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005802 trans-Golgi network
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0016020 membrane
GO:0030496 midbody
GO:0090543 Flemming body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8atu, PDBe:8atu, PDBj:8atu
PDBsum8atu
PubMed36758105
UniProtQ9NR09|BIRC6_HUMAN Baculoviral IAP repeat-containing protein 6 (Gene Name=BIRC6)

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