Structure of PDB 8ati Chain A

Receptor sequence
>8atiA (length=330) Species: 9606 (Homo sapiens) [Search protein sequence]
RPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMY
HTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVE
ETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGET
LGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDL
LYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALA
QALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLE
MREAAATEIRRAITGRIPESLRNCVNKEFF
3D structure
PDB8ati Human CtBP2(31-364) in complex with RAI2 peptide(315-322)
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A C44 M48 V57 A58 F59 C60 E67 H69 C12 M16 V25 A26 F27 C28 E35 H37
BS02 NAD A S106 T134 G187 G189 R190 T191 D210 P211 Y212 H242 C243 N244 A270 R272 H321 A323 W324 S74 T102 G155 G157 R158 T159 D178 P179 Y180 H210 C211 N212 A238 R240 H289 A291 W292
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding

View graph for
Molecular Function
External links
PDB RCSB:8ati, PDBe:8ati, PDBj:8ati
PDBsum8ati
PubMed
UniProtP56545|CTBP2_HUMAN C-terminal-binding protein 2 (Gene Name=CTBP2)

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