Structure of PDB 8arj Chain A

Receptor sequence
>8arjA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
SSISDLKEVPRKNITLIRGLGHEVYEGQVPLQVAVKTLPEVCSEQDELDF
LMEALIISKFNHQNIVRCIGVSLQSLPRFILLELMAGGDLKSFLRETRPR
PSQSLAMLDLLHVARDIACGCQYLEENHFIHRDIAARNCLLTCPGPGRVA
KIGDFGMARDIGGCAMLPVKWMPPEAFMEGIFTSKTDTWSFGVLLWEIFS
LGYMPYPSKSNQEVLEFVTSGGRMDPPKNCPGPVYRIMTQCWQHQPEDRP
NFAIILERIEYCTQDPDVINTALPI
3D structure
PDB8arj Discovery of Novel alpha-Carboline Inhibitors of the Anaplastic Lymphoma Kinase.
ChainA
Resolution1.645 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NRR A A1148 K1150 L1196 M1199 G1202 E1210 L1256 G1269 D1270 A34 K36 L82 M85 G88 E96 L140 G153 D154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8arj, PDBe:8arj, PDBj:8arj
PDBsum8arj
PubMed35647450
UniProtQ9UM73|ALK_HUMAN ALK tyrosine kinase receptor (Gene Name=ALK)

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