Structure of PDB 8aqm Chain A

Receptor sequence
>8aqmA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
MQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYD
MNSLMMGEEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTL
LKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPK
FEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQAL
ELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKMSLHPLLQEI
YKDLY
3D structure
PDB8aqm Discovery and Structure-Based Design of Potent Covalent PPAR gamma Inverse-Agonists BAY-4931 and BAY-0069 .
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V293 T297 K301 L311 V315 L318 K319 H323 V76 T80 K84 L94 V98 L101 K102 H106
BS02 O2O A I281 F282 C285 Q286 Y320 H323 F363 H449 Y473 L476 Y477 I64 F65 C68 Q69 Y103 H106 F146 H232 Y251 L254 Y255
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8aqm, PDBe:8aqm, PDBj:8aqm
PDBsum8aqm
PubMed36270630
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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