Structure of PDB 8aqk Chain A

Receptor sequence
>8aqkA (length=40) Species: 64320 (Zika virus) [Search protein sequence]
VDMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVE
3D structure
PDB8aqk Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2258
ChainA
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D83 F84 D35 F36
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:8aqk, PDBe:8aqk, PDBj:8aqk
PDBsum8aqk
PubMed38809037
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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