Structure of PDB 8apw Chain A

Receptor sequence
>8apwA (length=250) Species: 727 (Haemophilus influenzae) [Search protein sequence]
SSGLVPRGSHMWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRD
FTFDKHKTVDDRPYGGGPGMLMMVQPLRDAIHTAKAAAGEGAKVIYLSPQ
GRKLDQGGVTELAQNQKLILVCGRYEGIDERLIQTEIDEEWSIGDYVLTG
GELPAMTLIDAVARFIPGVLGEEDSFADGLLDCPHYTRPEVLEGLTVPPV
LMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEAQAEHN
3D structure
PDB8apw Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
ChainA
Resolution1.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.228: tRNA (guanine(37)-N(1))-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NL1 A L87 S88 P89 E116 S132 I133 Y136 L138 G140 G141 P144 L97 S98 P99 E126 S142 I143 Y146 L148 G150 G151 P154
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity
GO:0052906 tRNA (guanine(37)-N1)-methyltransferase activity
Biological Process
GO:0002939 tRNA N1-guanine methylation
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8apw, PDBe:8apw, PDBj:8apw
PDBsum8apw
PubMed37187252
UniProtA5UG04|TRMD_HAEIG tRNA (guanine-N(1)-)-methyltransferase (Gene Name=trmD)

[Back to BioLiP]