Structure of PDB 8an8 Chain A

Receptor sequence
>8an8A (length=244) Species: 9606 (Homo sapiens) [Search protein sequence]
PSSLIVHFNEVIGRGHFGCVYHGTLLKIHCAVKSGEVSQFLTEGIIMFSH
PNVLSLLGICLPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKG
MKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYPVKWMA
LESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRR
LLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFI
3D structure
PDB8an8 Discovery of a selective c-MET inhibitor with a novel binding mode
ChainA
Resolution2.394 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MDI A F1089 A1108 K1110 E1120 V1121 S1122 L1125 L1157 Y1159 M1160 M1211 D1222 F1223 F17 A31 K33 E36 V37 S38 L41 L66 Y68 M69 M120 D131 F132
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8an8, PDBe:8an8, PDBj:8an8
PDBsum8an8
PubMed35987508
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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