Structure of PDB 8amq Chain A

Receptor sequence
>8amqA (length=464) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
AHHHHHHKVRLDPSRCVGHAQCYAVDPDLFPIDDSGNSILAEHEVRPEDM
QLTRDGVAACPEMALILEEDDADVLHRHQPAGSFYLPRLEYSTLPMAVDR
GVGWKTLRDAGPVVFMNGWYYLTRREDVLAALRNPKVFSSRKALQPPNPL
PVVPLAFDPPEHTRYRRILQPYFSPAALSKALPSLRRHTVAMIDAIAGRG
ECEAMADLANLFPFQLFLVLYGLPLEDRDRLIGWKDAVIAMSDRPHPTEA
DVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLSEIEVLGLSHLL
ILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLEPSA
PVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKV
HRHWGFGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFP
SKSFALKNLPLRWS
3D structure
PDB8amq Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F3S A C10 G12 H13 A14 Q15 C16 S32 C54 L59 C16 G18 H19 A20 Q21 C22 S38 C60 L65
BS02 HEM A P1083 L1084 H1091 R1095 G1233 T1236 R1284 F1335 G1336 H1340 C1342 L1343 G1344 P154 L155 H162 R166 G304 T307 R355 F406 G407 H411 C413 L414 G415
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0051538 3 iron, 4 sulfur cluster binding

View graph for
Molecular Function
External links
PDB RCSB:8amq, PDBe:8amq, PDBj:8amq
PDBsum8amq
PubMed36699703
UniProtO53937;
P9WPL3|CP143_MYCTU Cytochrome P450 143 (Gene Name=cyp143)

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