Structure of PDB 8ake Chain A

Receptor sequence

>8akeA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]

PFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGISTAS
GIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRF
LVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGL
KATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITLGTS
LQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLM
KHLGLEIPAWDGPRVLERALPPLPRPPTPKLE

3D structure

PDB

8ake Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen

Chain

Resolution

1.82 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
2.4.2.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	AR6	A	G52 A53 G54 T57 D63 F64 R65 W71 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 Y257 V258	G43 A44 G45 T48 D54 F55 R56 W62 Q104 H124 G198 T199 S200 I203 N224 L225 Q226 Y241 V242
BS02	ZN	A	C141 C144 C166 C177	C132 C135 C157 C161
BS03	NCA	A	I61 P62 F64 F86 N114 V115 D116	I52 P53 F55 F77 N105 V106 D107

Gene Ontology

	Molecular Function
GO:0070403	NAD+ binding

View graph for
Molecular Function

External links

PDB	RCSB:8ake, PDBe:8ake, PDBj:8ake
PDBsum	8ake
PubMed
UniProt	Q8N6T7\|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)

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