Structure of PDB 8ak9 Chain A

Receptor sequence
>8ak9A (length=285) Species: 9606 (Homo sapiens) [Search protein sequence]
GIDPFTADKGKCGLPEIFDPPEELERKVWELARLVWQSSSVVFHTGAGIS
TASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGL
LRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGT
MGLKATGRLCTVACRGELRDTILDWEDSLPDRDLALADEASRNADLSITL
GTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMT
RLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLE
3D structure
PDB8ak9 Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.286: protein acetyllysine N-acetyltransferase.
2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AR6 A G52 G54 T57 D63 F64 R65 Q113 H133 G214 T215 S216 I219 N240 L241 Q242 G256 Y257 V258 G46 G48 T51 D57 F58 R59 Q107 H127 G201 T202 S203 I206 N227 L228 Q229 G243 Y244 V245
BS02 ZN A C141 C144 C166 C177 C135 C138 C160 C164
BS03 ISN A I8 F64 F82 I2 F58 F76
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:8ak9, PDBe:8ak9, PDBj:8ak9
PDBsum8ak9
PubMed
UniProtQ8N6T7|SIR6_HUMAN NAD-dependent protein deacylase sirtuin-6 (Gene Name=SIRT6)

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