Structure of PDB 8ak3 Chain A

Receptor sequence
>8ak3A (length=294) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
GPYDIGDELGRGTQGITYHAVERSSGDNYAAKIMYGRPELRPFMLNELEM
MNTFNHKNLIRPYDAYDTDRSVTLIMELAAGGELVRDNLLRRDYYTERDI
AHYIRQTLWGLEHMHEMGVGHMGLTIKDLLISVVGGDIIKVSDFGLSRKI
NRHNLSTLDYGMPEFVSPEVVNKEGVNFSHDMWTVGLITYVLLGGHNPFL
GIDDRETLTKIREGRWDFKDEIWTHISDDGRDFISRLLLYSPEERMDVKT
ALKHPWFFMLDRPVYDHDYQIGTDRLRNYYDHFRDWYANASCKN
3D structure
PDB8ak3 PK1 from Drosophila obscurin is an inactive pseudokinase with scaffolding properties.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G3193 R3194 G3195 T3196 Q3197 G3198 T3200 A3213 K3215 M3259 E3260 A3262 E3266 K3310 L3313 D3326 G10 R11 G12 T13 Q14 G15 T17 A30 K32 M76 E77 A79 E83 K127 L130 D143
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:8ak3, PDBe:8ak3, PDBj:8ak3
PDBsum8ak3
PubMed37121260
UniProtA8DYP0|OBSCN_DROME Obscurin (Gene Name=Unc-89)

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