Structure of PDB 8afb Chain A

Receptor sequence
>8afbA (length=164) Species: 9606 (Homo sapiens) [Search protein sequence]
TEYKLVVVGACGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETC
LLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIK
RVKDSEDVPMVLVGNKSDLPSRTVDTKQAQDLARSYGIPFIETSAKTRQG
VDDAFYTLVREIRK
3D structure
PDB8afb Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor.
ChainA
Resolution1.12 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.2: small monomeric GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A C12 G13 V14 G15 K16 S17 A18 D30 N116 K117 D119 L120 S145 A146 C11 G12 V13 G14 K15 S16 A17 D29 N115 K116 D118 L119 S144 A145
BS02 LXD A C12 P34 A59 G60 Q61 E62 E63 R68 D69 M72 H95 Y96 C11 P33 A58 G59 Q60 E61 E62 R67 D68 M71 H94 Y95
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
Biological Process
GO:0007165 signal transduction
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:8afb, PDBe:8afb, PDBj:8afb
PDBsum8afb
PubMed36300829
UniProtP01116|RASK_HUMAN GTPase KRas (Gene Name=KRAS)

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