Structure of PDB 8aed Chain A

Receptor sequence

>8aedA (length=160) Species: 32630 (synthetic construct) [Search protein sequence]

DLGKKLLEAAYYGQLDEVRILMANGADVNAVDVHGITPLHLAAYFGHLEI
VEVLLKTGADVNARDNRGITPLHLAAAMGHLEIVEVLLKAGADVNAFDEA
GDTPLHLAALKGHLEIVEVLLKHGADVNAQDKFGKTAFDISIDNGNEDIA
EVLQKAAKLN

3D structure

PDB

8aed Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.

Chain

Resolution

1.17 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	Y13 H36 Y46 F47 D67 R69 I71 L76 A79 D100 D104 L112 K113 D133 F135	Y11 H34 Y44 F45 D65 R67 I69 L74 A77 D98 D102 L110 K111 D131 F133

External links

PDB	RCSB:8aed, PDBe:8aed, PDBj:8aed
PDBsum	8aed
PubMed	37605043

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