Structure of PDB 8acr Chain A

Receptor sequence
>8acrA (length=486) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
WTPGKPNPSICKSPLLVSTPLGLPRCLQASNVVKRLQKLEDIASLNDGNR
AAATPGYQASVDYVKQTLQKAGYKVSVQPFPFTAYYPKGPGSLSATVPQP
VTYEWEKDFTYLSQTEAGDVTAKVVPVDLSLGAGNTSTSGCEAEDFANFP
AGSIALIQRGTCNFEQKAENAAAAGAAGVIIFNQGNTDDRKGLENVTVGE
SYEGGIPVIFATYDNGVAWSQTPDLQLHLVVDVVRKKTETYNVVAETRRG
NPNNVVMVGAHLDSVFEGPGINDNGSGSAAQLEMAVLLAKALPVNKVRFA
WWGAAEAGLVGSTHYVQNLAPEEKKKIKAYLNFDMIGSPNFGNFIYDGDG
SDFGLQGPPGSAAIERLFEAYFRLRGQQSEGTEIDFRSDYAEFFNSGIAF
GGLFTGAEGLKTEEQAQKYGGTAGKAYDECYHSKCDGIANINQDALEIHS
DAMAFVTSWLSLSTKVVDDEIAAAGQIERWGHDFIK
3D structure
PDB8acr An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D308 E341 H467 D273 E306 H432
BS02 ZN A H296 D308 D369 H261 D273 D334
BS03 ZN A D382 D384 S386 E400 D347 D349 S351 E365
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0015628 protein secretion by the type II secretion system
GO:0043952 protein transport by the Sec complex
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8acr, PDBe:8acr, PDBj:8acr
PDBsum8acr
PubMed37386135
UniProtQ9HZQ8|LAP_PSEAE Aminopeptidase (Gene Name=lap)

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