Structure of PDB 8ac7 Chain A

Receptor sequence
>8ac7A (length=477) Species: 287 (Pseudomonas aeruginosa) [Search protein sequence]
SICKSPLLVSTPLGLPRCLQASNVVKRLQKLEDIASLNDGNRAAATPGYQ
ASVDYVKQTLQKAGYKVSVQPFPFTAYYPKGPGSLSATVPQPVTYEWEKD
FTYLSQTEAGDVTAKVVPVDLSLGAGNTSTSGCEAEDFANFPAGSIALIQ
RGTCNFEQKAENAAAAGAAGVIIFNQGNTDDRKGLENVTVGESYEGGIPV
IFATYDNGVAWSQTPDLQLHLVVDVVRKKTETYNVVAETRRGNPNNVVMV
GAHLDSVFEGPGINDNGSGSAAQLEMAVLLAKALPVNKVRFAWWGAEEAG
LVGSTHYVQNLAPEEKKKIKAYLNFDMIGSPNFGNFIYDGDGSDFGLQGP
PGSAAIERLFEAYFRLRGQQSEGTEIDFRSDYAEFFNSGIAFGGLFTGAE
GLKTEEQAQKYGGTAGKAYDECYHSKCDGIANINQDALEIHSDAMAFVTS
WLSLSTKVVDDEIAAAGIERWGHDFIK
3D structure
PDB8ac7 An anti-biofilm cyclic peptide targets a secreted aminopeptidase from P. aeruginosa.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.1: leucyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H296 D308 D369 H253 D265 D326
BS02 ZN A D308 E341 H467 D265 E298 H424
BS03 ZN A D382 D384 S386 E400 D339 D341 S343 E357
BS04 ZN A E482 D486 E439 D443
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ac7, PDBe:8ac7, PDBj:8ac7
PDBsum8ac7
PubMed37386135
UniProtQ02PA2|LAP_PSEAB Aminopeptidase (Gene Name=lap)

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