Structure of PDB 8ab5 Chain A

Receptor sequence
>8ab5A (length=178) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
AGPVTWVMMIACVVVFIAMQILGDQEVMLWLAWPFDPTLKFEFWRYFTHA
LMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITLISALLSGYVQQKF
SGPWFGGLSGVVYALMGYVWLRGERDPQSGIYLQRGLIIFALIWIVAGWF
DLFGMSMANGAHIAGLAVGLAMAFVDSL
3D structure
PDB8ab5 Structure of E. coli GlpG in complex with peptide derived inhibitor Ac-VRHA-conh-[4-(4-butyl)-phenoxy-1-phenyl-2-butyl]
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.105: rhomboid protease.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F146 H150 F153 N154 W196 F197 G198 G199 S201 Y205 W236 F245 M247 S248 M249 A250 H254 F54 H58 F61 N62 W104 F105 G106 G107 S109 Y113 W144 F153 M155 S156 M157 A158 H162
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8ab5, PDBe:8ab5, PDBj:8ab5
PDBsum8ab5
PubMed38901105
UniProtP09391|GLPG_ECOLI Rhomboid protease GlpG (Gene Name=glpG)

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