Structure of PDB 8aak Chain A

Receptor sequence

>8aakA (length=163) Species: 9606 (Homo sapiens) [Search protein sequence]

DPREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQ
INGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTITMHKDSTGHVG
FIFKNGKITSIVKDSSAARNGLLTEHNICEINGQNVIGLKDSQIADILST
SGTVVTITIMPAF

3D structure

PDB

8aak Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein-Protein Interaction: A Semi-Automated "Hit Identification-to-Optimization" Approach.

Chain

Resolution

2.554 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	LL6	A	H208 V209 F211 F213 D251 L258	H98 V99 F101 F103 D141 L148

External links

PDB	RCSB:8aak, PDBe:8aak, PDBj:8aak
PDBsum	8aak
PubMed	36939673
UniProt	O00560\|SDCB1_HUMAN Syntenin-1 (Gene Name=SDCBP)

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