Structure of PDB 8a9k Chain A

Receptor sequence
>8a9kA (length=998) Species: 9606 (Homo sapiens) [Search protein sequence]
AEEVEFVVEKALSMFSKMNLQEIPPLVYQLLVLSSKGSRKSVLEGIIAFF
SALDKQHNEEQSGDELLDVVTVPSGELRHVEGTIILHIVFAIKLDYELGR
ELVKHLKVGDSNNNLSPFSIALLLSVTRIQRFQDQVLDLLKTSVVKSFKD
LQLLQGSKFLQNLVPHRSYVSTMILEVVKNSVHSWDHVTQGLVELGFILM
DSYGPKKVSLSRMPNQHACKLGANILLETFKIHEMIRQEILEQVLNRVVT
RASSPISHFLDLLSNIVMYAPLVLQSCSSKVTEAFDYLSFLPLQTVQRLL
KAVQPLLKVSMSMRDCLILVLRKAMFANQLDARKSAVAGFLLLLKNFKVL
GSLLSVSQVHVDVHSHYNSVANETFCLEIMDSLRRCLSQQADVRLMLYEG
FYDVLRRNSQLANSVMQTLLSQLKQFYEPKPDLLPPLKLEACILTQKISL
QEPLDYLLCCIQHCLAWYKNTVIPFYEDLDDILESITNRMIKSELEDFEL
SADFSQSTSIGIKNNICAFLVMGVCEVLIEYNFSISSFSKNRFEDILSLF
MCYKKLSDILNEKATSDSLLSMKFVSSLLTALFRDSIQSHQESLSVLRSS
NEFMRYAVNVALQKVQQLKETGHVSGPDGQNPEKIFQNLCDITRVLLWRY
TSIPTGKSISLLCLEGLQKIFSAVQQFYQPKIQQFLRALDVSVTQRTAFQ
IRQFQRSLLNLLSSQEEDFNSKEALLLVTVLTSLSKLLEPSSPQFVQMLS
WTSKICKENSREDALFCKSLMNLLFSLHVSYKSPVILLRDLSQDIHGHLG
DIDQDVEVEKTNHFAIVNLRTAAPTVCLLVLSQAEKVLEEVDWLITKLKG
QVPNQPVEKAIIMQLGTLLTFFHELVQTALPSGSCVDTLLKDLCKMYTTL
TALVRYYLQVCQIPKNMEKLVKLSGSHLTPLCYSFISYVQNKSVATAMAR
VLRETKPIPNLIFAIEQYEKFLIHLSKKSKVNLMQHMKLSTSRDFKIK
3D structure
PDB8a9k Cryo-EM reveals a mechanism of USP1 inhibition through a cryptic binding site.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A T1238 R1242 T946 R950
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0070182 DNA polymerase binding
Biological Process
GO:0006281 DNA repair
GO:0031398 positive regulation of protein ubiquitination
GO:0036297 interstrand cross-link repair
Cellular Component
GO:0000785 chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:1990391 DNA repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a9k, PDBe:8a9k, PDBj:8a9k
PDBsum8a9k
PubMed36170365
UniProtQ9NVI1|FANCI_HUMAN Fanconi anemia group I protein (Gene Name=FANCI)

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