Structure of PDB 8a6x Chain A

Receptor sequence

>8a6xA (length=364) Species: 160488,224911 [Search protein sequence]

HMINAKLLQLMVEHSNDGIVVAEQEGNESILIYVNPAFERLTGYCADDIL
YQDCRFLQGEDHDQPGIAIIREAIREGRPCCQVLRNYRKDGSLFWNELSI
TPVHNEADQLTYYIGIQRDVTEHQQTQARLQELQSELVHVSRLSAMGEMA
SALAHELNQPLAAISNYMKGSRRLLAGSSDPNTPKVESALDRAAEQALRA
GQIIRRLRDFVARGESEKRVESLSKLIEEAGALGLAGAREQNVQLRFSLD
PGADLVLADRVQIQQVLVNLFRNALEAMAQSQRRELVVTNTPAADDMIEV
EVSDTGSGFQDDVIPNLFQTFFTTKDTGMGVGLSISRSIIEAHGGRMWAE
SNASGGATFRFTLP

3D structure

PDB

8a6x Crystal structure of a chimeric LOV-Histidine kinase SB2F1 (asymmetrical variant, trigonal form with long c axis)

Chain

Resolution

2.45 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.7.13.3: histidine kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ATP	A	N268 N272 A276 D303 L316 T322 T323 K324 G327 M328 G329 V330 G331 L332 A356 F358	N269 N273 A277 D304 L317 T323 T324 K325 G328 M329 G330 V331 G332 L333 A357 F359
BS02	FMN	A	V19 D52 C53 R54 L56 Q57 R70 L83 N85 N95 L97 I99 Y112 Q116	V20 D53 C54 R55 L57 Q58 R71 L84 N86 N96 L98 I100 Y113 Q117

Gene Ontology

	Molecular Function
GO:0000155	phosphorelay sensor kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

	Biological Process
GO:0007165	signal transduction
GO:0016310	phosphorylation

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:8a6x, PDBe:8a6x, PDBj:8a6x
PDBsum	8a6x
PubMed
UniProt	P23222\|FIXL_BRADU Sensor protein FixL (Gene Name=fixL); Q88JB0

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