Structure of PDB 8a5k Chain A

Receptor sequence
>8a5kA (length=562) Species: 557722 (Pseudomonas aeruginosa LESB58) [Search protein sequence]
LHEIPRERPATPLLDRASSPAELRRLGEADLETLADELRQYLLYTVGQTG
GHFGAGLGVVELTIALHYVFDTPDDRLVWDVGHQAYPHKILTERRELMGT
LRQKNGLAAFPRRAESEYDTFGVGHSSTSISAALGMAIAARLQGKERKSV
AVIGDGALTAGMAFEALNHASEVDADMLVILNDNDMSISHNVGGLSNYEL
GWNYIGPIDGHDLPTLVATLRNMRDMKGPQFLHVVTKKGKGFAPAELDPI
GYHAITKLTGGPKYSSVFGQWLCDMAAQDARLLGITPAMKEGSDLVAFSE
RYPERYFDVAIAEQHAVTLAAGMACEGMKPVVAIYSTFLQRAYDQLIHDV
AVQHLDVLFAIDRAGLVGEDGPTHAGSFDISYLRCIPGMLVMTPSDEDEL
RKLLTTGYLFDGPAAVRYPRGSGPNHPIDPDLQPVEIGKGVVRRRGGRVA
LLVFGVQLAEAMKVAESLDATVVDMRFVKPLDEALVRELAGSHELLVTIE
ENAVMGGAGSAVGEFLASEGLEVPLLQLGLPDYYVEHAKPSEMLAECGLD
AAGIEKAVRQRL
3D structure
PDB8a5k 1-deoxy-D-xylulose-5-phosphate synthase from Pseudomonas aeruginosa and Klebsiella pneumoniae reveals conformational changes upon cofactor binding.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TPP A H115 S158 G186 D187 G188 A189 N216 M218 S219 I220 K286 I368 E370 F395 R398 H83 S126 G154 D155 G156 A157 N184 M186 S187 I188 K238 I311 E313 F338 R341
BS02 MG A D187 N216 M218 D155 N184 M186
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8a5k, PDBe:8a5k, PDBj:8a5k
PDBsum8a5k
PubMed37567475
UniProtB7V7R4|DXS_PSEA8 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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