Structure of PDB 8a45 Chain A

Receptor sequence
>8a45A (length=567) Species: 557722 (Pseudomonas aeruginosa LESB58) [Search protein sequence]
LHEIPRERPATPLLDRASSPAELRRLGEADLETLADELRQYLLYTVGQTG
GHFGAGLGVVELTIALHYVFDTPDDRLVWDVGHQAYPHKILTERRELMGT
LRQKNGLAAFPRRAESEYDTFGVGHSSTSISAALGMAIAARLQGKERKSV
AVIGDGALTAGMAFEALNHASEVDADMLVILNDNDMSISHNVGGLSNYLT
LFEELGWNYIGPIDGHDLPTLVATLRNMRDMKGPQFLHVVTKKGKGFAPA
ELDPIGYHAITKLEGGPKYSSVFGQWLCDMAAQDARLLGITPAMKEGSDL
VAFSERYPERYFDVAIAEQHAVTLAAGMACEGMKPVVAIYSTFLQRAYDQ
LIHDVAVQHLDVLFAIDRAGLVGEDGPTHAGSFDISYLRCIPGMLVMTPS
DEDELRKLLTTGYLFDGPAAVRYPRGSGPNHPIDPDLQPVEIGKGVVRRR
GGRVALLVFGVQLAEAMKVAESLDATVVDMRFVKPLDEALVRELAGSHEL
LVTIEENAVMGGAGSAVGEFLASEGLEVPLLQLGLPDYYVEHAKPSEMLA
ECGLDAAGIEKAVRQRL
3D structure
PDB8a45 Structural analysis of 1-deoxy-D-xylulose 5-phosphate synthase from Pseudomonas aeruginosa with 2-acetyl thiamine diphosphate
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.2.1.7: 1-deoxy-D-xylulose-5-phosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HTL A A87 H115 G156 S158 G186 D187 G188 A189 N216 M218 I220 K286 I368 E370 F395 R398 A55 H83 G124 S126 G154 D155 G156 A157 N184 M186 I188 K243 I316 E318 F343 R346
BS02 MG A D187 N216 M218 D155 N184 M186
BS03 CA A D413 Y465 F467 D361 Y413 F415
BS04 CA A E558 L601 E506 L549
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity
Biological Process
GO:0016114 terpenoid biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8a45, PDBe:8a45, PDBj:8a45
PDBsum8a45
PubMed37567475
UniProtB7V7R4|DXS_PSEA8 1-deoxy-D-xylulose-5-phosphate synthase (Gene Name=dxs)

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