Structure of PDB 8a3n Chain A

Receptor sequence
>8a3nA (length=351) Species: 4058 (Catharanthus roseus) [Search protein sequence]
DLSVKAVGWGAADASGVLQPIKFYRRVPGERDVKIRVLYSGVCNFDMEMV
RNKWGFTRYPYVFGHETAGEVVEVGSKVEKFKVGDKVAVGCMVGSCGQCY
NCQSGMENYCPEPNMADGSVYQGERSYGGCSNVMVVDEKFVLRWPENLPQ
DKGVALLCAGVVVYSPMKHLGLDKPGKHIGVFGLGGLGSVAVKFIKAFGG
KATVISTSRRKEKEAIEEHGADAFVVNTDSEQLKALAGTMDGVVDTTPGG
RTPMSLMLNLLKFDGAVMLVGAPESLFELPAAPLIMGRKKIIGSSTGGLK
EYQEMLDFAAKHNIVCDTEVIGIDYLSTAMERIKNLDVKYRFAIDIGNTL
K
3D structure
PDB8a3n Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.3.1.36: geissoschizine dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A N52 V172 L194 L197 S216 T217 K221 T256 P258 R261 V280 A282 S305 R351 N44 V162 L184 L187 S206 T207 K211 T246 P248 R251 V270 A272 S295 R341
BS02 ZN A C51 H73 E74 C168 C43 H65 E66 C158
BS03 ZN A C104 C107 C110 C118 C96 C99 C102 C110
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0045551 cinnamyl-alcohol dehydrogenase activity
GO:0046872 metal ion binding
GO:0047920 geissoschizine dehydrogenase activity
Biological Process
GO:0009753 response to jasmonic acid
GO:0009809 lignin biosynthetic process
GO:0010272 response to silver ion
GO:0035834 indole alkaloid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:8a3n, PDBe:8a3n, PDBj:8a3n
PDBsum8a3n
PubMed36198083
UniProtW8JWW7|GS_CATRO Geissoschizine synthase (Gene Name=GS)

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