Structure of PDB 8a28 Chain A

Receptor sequence
>8a28A (length=382) Species: 6850 (Limulus polyphemus) [Search protein sequence]
ENLGDLPLYHSNLFEGDIAGVSPYADKNAIVDHTLLWPGGIVYYELAPAA
ASIRNQILEGMKEYHEKTCIQFKERTAGVKDYIRINRYDGCWSMVGRQGG
MQELSLGYGCEWKGLVVHALGHAVGFWHEQNRADRDDYIEVIWDNILQSM
QYNFNKMEPWENNYLNERFDYKSVMLYGETAFSKDGTSPTVRPKQPGVVI
GPVWKKPGFSESDVRRVNRLYECFGEVRPPPPKIPDFICDFESNDCGLEN
QVGMRGEFQRKYDTLGGRTGYFMVLSVTSSGTYADSRLITPYFGAYGNQD
VCMSVDVYMSGPAVRDVEISRQDSNTESIGKYTEVSNSWVTRNFNLKAGR
EDMRFFIFAALDPYYGDGVVAVDNLKFKRKPC
3D structure
PDB8a28 Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D38 H139 H143 H149 D17 H118 H122 H128
BS02 MG A H31 S32 G37 H10 S11 G16
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a28, PDBe:8a28, PDBj:8a28
PDBsum8a28
PubMed36322418
UniProtB4F320

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