Structure of PDB 8a0z Chain A

Receptor sequence
>8a0zA (length=202) Species: 498019 (Candidozyma auris) [Search protein sequence]
TRPKISLIVAALQPSMGIGAKGSLPWRLKNEMKYFKDVTSKAKDGHINAV
VMGRKTWELIPERFRPLAGRLNVILSRKNDDLIDSNGVYHFSSFDSVMKH
LEKDSFRFKDMPLDKIFIIGGSQIYNLLILDSRVDNLLVTQVHFVGEDAD
KPQMDTFLDWDLSKWKRLEHDKLEQYVGLDVPRGLNEEGSYNYEYTMWEK
AQ
3D structure
PDB8a0z Crystal structure of candida auris
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.3: dihydrofolate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A V10 A11 I19 S24 G54 R55 K56 T57 L60 L76 S77 R78 I120 G122 S123 Q124 I125 Y126 V9 A10 I18 S23 G53 R54 K55 T56 L59 L75 S76 R77 I119 G121 S122 Q123 I124 Y125
BS02 CP6 A I9 V10 E32 M33 F36 I120 I8 V9 E31 M32 F35 I119
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004146 dihydrofolate reductase activity
GO:0016491 oxidoreductase activity
GO:0050661 NADP binding
Biological Process
GO:0006730 one-carbon metabolic process
GO:0046452 dihydrofolate metabolic process
GO:0046654 tetrahydrofolate biosynthetic process
GO:0046655 folic acid metabolic process
Cellular Component
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a0z, PDBe:8a0z, PDBj:8a0z
PDBsum8a0z
PubMed
UniProtA0A0L0P1H8

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