Structure of PDB 8a0g Chain A

Receptor sequence
>8a0gA (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
STQVRGYDFNRGVNYRALLEAFGTTGFQATNFGRAVQQVNAMIEKKLEPL
SQDEDQHADLTQSRRPLTSCTIFLGYTSNLISSGIRETIRYLVQHNMVDV
LVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRENGINRIGNLLVPNENYC
KFEDWLMPILDQMVMEQNTEGVKWTPSKMIARLGKEINNPESVYYWAQKN
HIPVFSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKCTG
MIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSW
GKIRVDAQPVKVYADASLVFPLLVAETFAQKMDAFM
3D structure
PDB8a0g Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders.
ChainA
Resolution1.84 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.5.1.46: deoxyhypusine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 13D A H288 N292 X329 H261 N265 X302
BS02 NAD A T104 S105 N106 T131 A132 G133 E137 D238 G282 G283 N307 T308 A309 D342 A343 T77 S78 N79 T104 A105 G106 E110 D211 G255 G256 N280 T281 A282 D315 A316
BS03 NAD A G284 H288 D313 S315 D316 S317 X329 G257 H261 D286 S288 D289 S290 X302
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0034038 deoxyhypusine synthase activity
GO:0042802 identical protein binding
Biological Process
GO:0006412 translation
GO:0008216 spermidine metabolic process
GO:0008284 positive regulation of cell population proliferation
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0042102 positive regulation of T cell proliferation
GO:0042593 glucose homeostasis
GO:0046203 spermidine catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a0g, PDBe:8a0g, PDBj:8a0g
PDBsum8a0g
PubMed36973244
UniProtP49366|DHYS_HUMAN Deoxyhypusine synthase (Gene Name=DHPS)

[Back to BioLiP]