Structure of PDB 7zzi Chain A

Receptor sequence
>7zziA (length=463) Species: 5820 (Plasmodium) [Search protein sequence]
PINEELSWRINKFVNQLRISYSTLEEFVDNFVYELKKGLEAHRKHPNLWI
PHECSFKMLDSCIANIPTGQEKGTYYAIDFGGTNFRAVRASLDGKGKIKR
DQETYSLKFTGSYSHEKGLLDKHATASQLFDHFAERIKYIMGEFNDLDNK
EVKSVGFTFSFPCTSPSINCSILIDWTKGFETGRATNDPVEGRDVCKLMN
DAFVRAAIPAKVCCVLNDAVGTLMSCAYQKGRGTPPCYIGIILGTGSNGC
YYEPEWKKYKYAGKIINIEFGNFDKDLPTSPIDLVMDWYSANRSRQLFEK
MISGAYLGEIVRRFMVNVLQSACSKKMWISDSFNSESGSVVLNDTSKNFE
DSRKVAKAAWDMDFTDEQIYVLRKICEAVYNRSAALAAGTIAAIAKRIKI
IEHSKFTCGVDGSLFVKNAWYCKRLQEHLKVILADKAENLIIIPADDGSG
KGAAITAAVIALN
3D structure
PDB7zzi Structural Analysis of Plasmodium falciparum Hexokinase Provides Novel Information about Catalysis Due to a Plasmodium -Specific Insertion.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.-
2.7.1.1: hexokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLC A S183 F184 P185 T200 K201 N240 D241 N271 E292 E322 S160 F161 P162 T177 K178 N217 D218 N248 E269 E299
Gene Ontology
Molecular Function
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005524 ATP binding
GO:0005536 D-glucose binding
GO:0008865 fructokinase activity
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zzi, PDBe:7zzi, PDBj:7zzi
PDBsum7zzi
PubMed37628920
UniProtW7JZC2

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