Structure of PDB 7zyi Chain A

Receptor sequence
>7zyiA (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
GKRPTDLALSVILVFMLFFIMLSLGCTMEFSKIKAHLWKPKGLAIALVAQ
YGIMPLTAFVLGKVFRLKNIEALAILVCGCSPGGNLSNVFSLAMKGDMNL
SIVMTTCSTFCALGMMPLLLYIYSRGIYDGDLKDKVPYKGIVISLVLVLI
PCTIGIVLKSKRPQYMRYVIKGGMIIILLCSVAVTVLSAINVGKSIMFAM
TPLLIATSSLMPFIGFLLGYVLSALFCLNGRCRRTVSMETGCQNVQLCST
ILNVAFPPEVIGPLFFFPLLYMIFQLGEGLLLIAIFWCYEKFK
3D structure
PDB7zyi Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
ChainA
Resolution2.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0008508 bile acid:sodium symporter activity
GO:0015125 bile acid transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006869 lipid transport
GO:0014070 response to organic cyclic compound
GO:0015721 bile acid and bile salt transport
GO:0031667 response to nutrient levels
GO:0043627 response to estrogen
GO:0045471 response to ethanol
GO:0046718 symbiont entry into host cell
GO:0055085 transmembrane transport
GO:0071466 cellular response to xenobiotic stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zyi, PDBe:7zyi, PDBj:7zyi
PDBsum7zyi
PubMed35726088
UniProtQ14973|NTCP_HUMAN Hepatic sodium/bile acid cotransporter (Gene Name=SLC10A1)

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