Structure of PDB 7zyf Chain A

Receptor sequence
>7zyfA (length=852) Species: 9606 (Homo sapiens) [Search protein sequence]
GKLFPWAQIRLPTAVVPLRYELSLHPNLTSMTFRGSVTISVQALQVTWNI
ILHSTGHNISRVTFMSQEKQAEILEYAYHGQIAIVAPEALLAGHNYTLKI
EYSANISSSYYGFYGFSYTDESNEKKYFAATQFEPLAARSAFPCFDEPAF
KATFIIKIIRDEQYTALSNMPKKSSVVLDDGLVQDEFSESVKMSTYLVAF
IVGEMKNLSQDVNGTLVSIYAVPEKIGQVHYALETTVKLLEFFQNYFEIQ
YPLKKLDLVAIPDFEAGAMENWGLLTFREETLLYDSNTSSMADRKLVTKI
IAHELAHQWFGNLVTMKWWNDLWLNEGFATFMEYFSLEKIFKELSSYEDF
LDARFKTMKKDSLNSSHPISSSVQSSEQIEEMFDSLSYFKGSSLLLMLKT
YLSEDVFQHAVVLYLHNHSYASIQSDDLWDSFNEVTTLDVKRMMKTWTLQ
KGFPLVTVQKKGKELFIQQERFFLNSYLWHIPLSYVTEGRNYSKYQSVSL
LDKKSGVINLTEEVLWVKVNINMNGYYIVHYADDDWEALIHQLKINPYVL
SDKDRANLINNIFELAGLGKVPLKRAFDLINYLGNENHTAPITEALFQTD
LIYNLLEKLGYMDLASRLVTRVFKLLQNQIQQQTWTDEGTPSMRELRSAL
LEFACTHNLGNCSTTAMKLFDDWMASNGTQSLPTDVMTTVFKVGAKTDKG
WSFLLGKYISIGSEAEKNKILEALASSEDVRKLYWLMKSSLNGDNFRTQK
LSFIIRTVGRHFPGHLLAWDFVKENWNKLVQKFPLGSYTIQNIVAGSTYL
FSTKTHLSEVQAFFENQSEATFRLRCVQEALEVIQLNIQWMEKNLKSLTW
WL
3D structure
PDB7zyf Discovery of Selective Nanomolar Inhibitors for Insulin-Regulated Aminopeptidase Based on alpha-Hydroxy-beta-amino Acid Derivatives of Bestatin.
ChainA
Resolution2.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.3: cystinyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A E285 K286 E124 K125
BS02 ZN A H464 H468 E487 H303 H307 E326
BS03 KFR A Q293 E295 P296 A427 G428 A429 M430 E431 H464 E465 H468 E487 Y549 Y961 Q132 E134 P135 A266 G267 A268 M269 E270 H303 E304 H307 E326 Y388 Y788
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7zyf, PDBe:7zyf, PDBj:7zyf
PDBsum7zyf
PubMed35833347
UniProtQ9UIQ6|LCAP_HUMAN Leucyl-cystinyl aminopeptidase (Gene Name=LNPEP)

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