Structure of PDB 7zy6 Chain A

Receptor sequence
>7zy6A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence]
WKVVEDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDA
AMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPT
LVITEYCCYGDLLNFLRRKRDELALDLEDLLSFSYQVAKGMAFLASKNCI
HRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARLPVKWMAPE
SIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRM
LSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISEST
3D structure
PDB7zy6 Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.
ChainA
Resolution3.09 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 KCI A W557 L595 K623 E640 L644 V654 T670 Y672 C673 L799 C809 D810 F811 W1 L29 K57 E74 L78 V88 T104 Y106 C107 L160 C170 D171 F172
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7zy6, PDBe:7zy6, PDBj:7zy6
PDBsum7zy6
PubMed36728508
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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