Structure of PDB 7zw8 Chain A

Receptor sequence
>7zw8A (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
EVQWKVVEEVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAY
GLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGA
CTIGGPTLVITEYCCYGDLLNFLRRKRDDELALDLEDLLSFSYQVAKGMA
FLASKNCIHRDLAARNILLTHGRITKICDFGLARDIKNDSNYVVKGNARL
PVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYK
MIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIEKQISES
T
3D structure
PDB7zw8 Identification of M4205─A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors.
ChainA
Resolution2.119 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K3R A W557 L595 V603 A621 L644 V654 T670 Y672 C673 G676 L799 C809 D810 F811 W4 L36 V44 A62 L85 V95 T111 Y113 C114 G117 L168 C178 D179 F180
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7zw8, PDBe:7zw8, PDBj:7zw8
PDBsum7zw8
PubMed36728508
UniProtP10721|KIT_HUMAN Mast/stem cell growth factor receptor Kit (Gene Name=KIT)

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