Structure of PDB 7zw7 Chain A

Receptor sequence
>7zw7A (length=408) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SVGIVYGDQYRQLCCSSPKFGDRYALVMDLINAYKLIPELSRVPPLQWDS
PSRMYEAVTAFHSTEYVDALKKLQMLHCEEKELTADDELLMDSFSLNYDC
PGFPSVFDYSLAAVQGSLAAASALICRHCEVVINWGGGWHHAKRSEASGF
CYLNDIVLAIHRLVSSTPRQTRVLYVDLDLHHGDGVEEAFWYSPRVVTFS
VHHASPGFFPGTGTWNMNDKLPIFLNGAGRGRFSAFNLPLEEGINDLDWS
NAIGPILDSLNIVIQPSYVVVQCGADCLATDPHRIFRLTNFYPSLSGYLY
AIKKILSWKVPTLILGGGGYNFPDTARLWTRVTALTIEEVKGKKMTLSPE
IPEHSYFSRYGPDFELDIDYFPHEDSIQKHHRRILEQLRNYADLNKLIYD
YDQVYQLY
3D structure
PDB7zw7 Crystal structure of Schistosoma mansoni HDAC8 in complex with a formate molecule in the active site
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.1.98: histone deacetylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D186 H188 D285 D179 H181 D276
Gene Ontology
Molecular Function
GO:0004407 histone deacetylase activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006338 chromatin remodeling
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zw7, PDBe:7zw7, PDBj:7zw7
PDBsum7zw7
PubMed
UniProtA0A3Q0KJ63

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