Structure of PDB 7zpk Chain A

Receptor sequence
>7zpkA (length=1280) Species: 10090 (Mus musculus) [Search protein sequence]
KYQVELLEAALDHNTIVCLNTGSGKTFIAVLLTKELAHQIRGDLNPHAKR
TVFLVNSANQVAQQVSAVRTHSDLKVGEYSDLEVNASWTKERWSQEFTKH
QVLIMTCYVALTVLKNGYLSLSDINLLVFDECHLAILDHPYREIMKLCES
CPSCPRILGLTASILNGKCDPEELEEKIQKLERILRSDAETATDLVVLDR
YTSQPCEIVVDCGPFTDRSGLYERLLMELEAALDFINDCNVAVHSKERDS
TLISKQILSDCRAVLVVLGPWCADKVAGMMVRELQKYIKHEQEELHRKFL
LFTDTLLRKIHALCEEYFSPASLDLKYVTPKVMKLLEILRKYILCGIIFV
ERRYTAVVLNRLIKEAGKQDPELAYISSNFITEFRKQEEVLRKFRAHETN
LLIATSVVEEGVDIPKCNLVVRFDLPTEYRSYVQSKGRARAPISNYVMLA
DTDKIKSFEEDLKTYKAIEKILRNKCSKPPYVLRPDDGGPRVTINTAIGH
INRYCARLPSDPFTHLAPKCRTRELPDGTFYSTLYLPINSPLRASIVGPP
MDSVRLAERVVALICCEKLHKIGELDEHLMRPGSTKRRQCYPKAIPECLR
ESYPKPDQPCYLYVIGMVLTTPLPDELNFRRRKLYPPEDTTRCFGILTAK
PIPQIPHFPVYTRSGEVTISIELKKSGFTLSQQMLELITRLHQYIFSHIL
RLEKPALEFKPTGAESAYCVLPLNVVNDSGTLDIDFKFMEDIEKSEARIG
IPSTKYSKETPFVFKLEDYQDAVIIPRYRNFDQPHRFYVADVYTDLTPLS
KFPSPEYETFAEYYKTKYNLDLTNLNQPLLDVDHTSSRLNLLTPRHLVPE
LCAIHPIPASLWRKAVCLPSILYRLHCLLTAEELRAQTASLGPNPGLILQ
ALTLSNASDGFNLERLEMLGDSFLKHAITTYLFCTYPDAHEGRLSYMRSK
KVSNCNLYRLGKKKGLPSRMVVSIFDPPVNWLPPGYVVNQDLHTEQCIAD
KSIADCVEALLGCYLTSCGERAAQLFLCSLGLKVLPVIPDAEKTLNHLIS
GFETFEKKINYRFKNKAYLLQAFTHASYHYNTITDCYQRLEFLGDAILDY
LITKHLYEDPRQHSPGVLTDLRSALVNNTIFASLAVKYDYHKYFKAVSPE
LFHVIDDFVKFQLEKIEVPKAMGDIFESLAGAIYMDSGMSLEVVWQVYYP
MMQPLIEKFSANVPRSPVRELLEMEPETAKFSPAERTYDGKVRVTVEVVG
KGKFKGVGRSYRIAKSAAARRALRSLKANQ
3D structure
PDB7zpk Structural and functional basis of mammalian microRNA biogenesis by Dicer.
ChainA
Resolution3.81 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R327 R459 Y936 R937 Y971 K975 L1033 Y1868 G1882 K1883 R282 R361 Y778 R779 Y813 K817 L847 Y1238 G1252 K1253
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0004525 ribonuclease III activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters
GO:0035198 miRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001525 angiogenesis
GO:0001834 trophectodermal cell proliferation
GO:0001932 regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0007284 spermatogonial cell division
GO:0008283 cell population proliferation
GO:0008593 regulation of Notch signaling pathway
GO:0009791 post-embryonic development
GO:0010070 zygote asymmetric cell division
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0010626 negative regulation of Schwann cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010660 regulation of muscle cell apoptotic process
GO:0014040 positive regulation of Schwann cell differentiation
GO:0014835 myoblast differentiation involved in skeletal muscle regeneration
GO:0019827 stem cell population maintenance
GO:0021522 spinal cord motor neuron differentiation
GO:0021675 nerve development
GO:0021889 olfactory bulb interneuron differentiation
GO:0021987 cerebral cortex development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030422 siRNA processing
GO:0030856 regulation of epithelial cell differentiation
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0031054 pre-miRNA processing
GO:0031069 hair follicle morphogenesis
GO:0031508 pericentric heterochromatin formation
GO:0031641 regulation of myelination
GO:0031643 positive regulation of myelination
GO:0032290 peripheral nervous system myelin formation
GO:0035116 embryonic hindlimb morphogenesis
GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196 miRNA processing
GO:0035264 multicellular organism growth
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0045069 regulation of viral genome replication
GO:0045589 regulation of regulatory T cell differentiation
GO:0045664 regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0048255 mRNA stabilization
GO:0048536 spleen development
GO:0048565 digestive tract development
GO:0048608 reproductive structure development
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048730 epidermis morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048812 neuron projection morphogenesis
GO:0050727 regulation of inflammatory response
GO:0050767 regulation of neurogenesis
GO:0051216 cartilage development
GO:0051225 spindle assembly
GO:0051252 regulation of RNA metabolic process
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0055013 cardiac muscle cell development
GO:0060119 inner ear receptor cell development
GO:0060253 negative regulation of glial cell proliferation
GO:0060576 intestinal epithelial cell development
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061548 ganglion development
GO:0070173 regulation of enamel mineralization
GO:0070922 RISC complex assembly
GO:0071335 hair follicle cell proliferation
GO:0098795 global gene silencing by mRNA cleavage
GO:2000628 regulation of miRNA metabolic process
GO:2000630 positive regulation of miRNA metabolic process
GO:2000736 regulation of stem cell differentiation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0048471 perinuclear region of cytoplasm
GO:0070578 RISC-loading complex
GO:0098978 glutamatergic synapse
GO:0099092 postsynaptic density, intracellular component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zpk, PDBe:7zpk, PDBj:7zpk
PDBsum7zpk
PubMed36332606
UniProtQ8R418|DICER_MOUSE Endoribonuclease Dicer (Gene Name=Dicer1)

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