Structure of PDB 7zo5 Chain A

Receptor sequence
>7zo5A (length=266) Species: 40324 (Stenotrophomonas maltophilia) [Search protein sequence]
EVPLPQLRAYTVDASWLQPMAPLQIADHTWQIGTEDLTALLVQTPDGAVL
LDGGMPQMASHLLDNMKARGVTPRDLRLILLSHAHADHAGPVAELKRRTG
AKVAANAESAVLLARGGSDDLHFGDGITYPPANADRIVMDGEVITVGGIV
FTAHFMAGHTPGSTAWTWTDTRNGKPVRIAYADSLSAPGYQLQGNPRYPH
LIEDYRRSFATVRALPCDVLLTPHPGASNWDYAAGARAGAKALTCKAYAD
AAEQKFDGQLAKETAG
3D structure
PDB7zo5 Interactions of hydrolyzed beta-lactams with the L1 metallo-beta-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products.
ChainA
Resolution1.43 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D88 H89 H225 D87 H88 H224
BS02 ZN A H84 H86 H160 H83 H85 H159
BS03 JO9 A Y11 W17 H86 D88 F124 H160 S185 S187 H225 Y10 W16 H85 D87 F123 H159 S184 S186 H224
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0030655 beta-lactam antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:7zo5, PDBe:7zo5, PDBj:7zo5
PDBsum7zo5
PubMed36924941
UniProtP52700|BLA1_STEMA Metallo-beta-lactamase L1 type 3

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