Structure of PDB 7zls Chain A

Receptor sequence
>7zlsA (length=157) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSD
YLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYY
VQMCKDVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYL
EEYKFQV
3D structure
PDB7zls Structure-based design of a phosphotyrosine-masked, cell-penetrant small molecule covalently targeting Cys111 on the E3 ligase SOCS2
ChainA
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JH9 A V55 K59 R73 S75 S76 T83 P92 T93 N94 R96 I110 C111 V148 L150 V26 K30 R44 S46 S47 T54 P63 T64 N65 R67 I81 C82 V107 L109
Gene Ontology
Biological Process
GO:0035556 intracellular signal transduction

View graph for
Biological Process
External links
PDB RCSB:7zls, PDBe:7zls, PDBj:7zls
PDBsum7zls
PubMed37816714
UniProtO14508|SOCS2_HUMAN Suppressor of cytokine signaling 2 (Gene Name=SOCS2)

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