Structure of PDB 7zlc Chain A

Receptor sequence
>7zlcA (length=39) Species: 64320 (Zika virus) [Search protein sequence]
DMYIERAGDITWEKDAEVTGNSPRLDVALDESGDFSLVE
3D structure
PDB7zlc Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs.
ChainA
Resolution1.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IXU A D83 F84 D34 F35
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Cellular Component
GO:0044423 virion component

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Molecular Function
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Cellular Component
External links
PDB RCSB:7zlc, PDBe:7zlc, PDBj:7zlc
PDBsum7zlc
PubMed36480352
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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