Structure of PDB 7zjs Chain A

Receptor sequence
>7zjsA (length=929) Species: 9606 (Homo sapiens) [Search protein sequence]
NMMLFEVVKMGKSAMQSVVDDWIESYKHDRDIALLDLINFFIQCSGCKGV
VTAEMFRHMQNSEIIRKMTEEFDEDSGDYPLTMAGPQWKKFKSSFCEFIG
VLVRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTAL
VNVALNLSINMDNTQRQYEAERNKANERLELLLQKRKELQENQDEIENMM
NAIFKGVFVHRYRDAIAEIRAICIEEIGIWMKMYSDAFLNDSYLKYVGWT
MHDKQGEVRLKCLTALQGLYYNKELNSKLELFTSRFKDRIVSMTLDKEYD
VAVQAIKLLTLVLQSSEEVLTAEDCENVYHLVYSAHRPVAVAAGEFLYKK
LFSGPNANLVKTLVFFFLESELHEHAAYLVDSMWDCATELLKDWECMNSL
LLEEEALTDRQESALIEIMLCTIRQAAECHPPVGRGTGRKVLTAKEKKTQ
LDDRTKITELFAVALPQLLAKYSVDAEKVTNLLQLPQYFDLEIYTTGRLE
KHLDALLRQIRNIVEKHTDTDVLEACSKTYHALCNEEFTIFNRVDISRSQ
LIDELADKFNRLLEDFLQEGEEPDEDDAYQVLSTLKRITAFHNAHDLSKW
DLFACNYKLLKTGIENGDMPEQIVIHALQCTHYVILWQLAKITESSSTKE
DLLRLKKQMRVFCQICQHYLTNVNTTVKEQAFTILCDILMIFSHQIMSGG
RDMLEPLVYTPDSSLQSELLSFILDHVFIEQDDEDEASKIEALHKRRNLL
AAFCKLIVYTVVEMNTAADIFKQYMKYYNDYGDIIKETMSKTRQIDKIQC
AKTLILSLQQLFNEMIQENGYNFDRSSSTFSGIKELARRFALTFLKTREA
IAMLHKDGIEFAFKEPNPQGESHPPLNLAFLDILSEFSSKLLRQDKRTVY
VYLEKFMTFQMSLRREDVWLPLMSYRNSL
3D structure
PDB7zjs Structural basis of centromeric cohesion protection.
ChainA
Resolution3.24 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A Y297 R298 D326 K330 Y331 W334 F367 Y212 R213 D241 K245 Y246 W249 F282
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007062 sister chromatid cohesion
GO:0034087 establishment of mitotic sister chromatid cohesion
GO:0051301 cell division
GO:0051321 meiotic cell cycle
GO:0090307 mitotic spindle assembly
Cellular Component
GO:0000775 chromosome, centromeric region
GO:0000785 chromatin
GO:0001650 fibrillar center
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0008278 cohesin complex
GO:0016020 membrane
GO:0016363 nuclear matrix
GO:0030892 mitotic cohesin complex
GO:0097431 mitotic spindle pole

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zjs, PDBe:7zjs, PDBj:7zjs
PDBsum7zjs
PubMed37081319
UniProtQ8N3U4|STAG2_HUMAN Cohesin subunit SA-2 (Gene Name=STAG2)

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