Structure of PDB 7zii Chain A

Receptor sequence
>7ziiA (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPWFPKKISDLDHCANRVLELDADHPGFKDNVYRKRRKYFADLAMNYKH
GDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYR
EDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVR
HSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQK
LATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPK
ITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIK
3D structure
PDB7zii Structure-Based Design of Xanthine-Benzimidazole Derivatives as Novel and Potent Tryptophan Hydroxylase Inhibitors.
ChainA
Resolution1.628 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.16.4: tryptophan 5-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H272 H277 E317 H165 H170 E210
BS02 IVQ A G234 Y235 L236 P238 F241 P268 H272 E317 G127 Y128 L129 P131 F134 P161 H165 E210
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
Biological Process
GO:0009072 aromatic amino acid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7zii, PDBe:7zii, PDBj:7zii
PDBsum7zii
PubMed35921615
UniProtP17752|TPH1_HUMAN Tryptophan 5-hydroxylase 1 (Gene Name=TPH1)

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