Structure of PDB 7zes Chain A

Receptor sequence
>7zesA (length=827) Species: 9606 (Homo sapiens) [Search protein sequence]
PLVVEPSYPDLVINVGEVTLGEENRKKLQKIQRDQEKERVMRAACALLNS
GGGVIRMAKKVEHPVEMGLDLEQSLRELIQSSDLQAFFETKQQGRCFYIF
VKSWSSGPFPEDRSVKPRLCSLSSSLYRRSETSVRSMDSREAFCFLKTKR
KPDPADLIFQKDYLEYGEILPFPESQLVEFKQFSTKHFQEYVKRTIPEYV
PAFANTGGGYLFIGVDDKSREVLGCAKENVDPDSLRRKIEQAIYKLPCVH
FCQPQRPITFTLKIVNVLKRGELYGYACMIRVNPFCCAVFSEAPNSWIVE
DKYVCSLTTEKWVGMMTDVYSKKGLEHKKELQQLLFSVPPGYLRYTPESL
WRDLISEHRGLEELINKQMQPFFRGILIFSRSWAVDLNLQEKPGVICDAL
LIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRA
KVLCLSPVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCE
VLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHC
EAHRILYVCENQPLRNFISDRNICRAETRKTFLRENFEHIQHIVIDEAQN
FRTEDGDWYGKAKSITRRAKGGPGILWIFLDYFQTSHLDCSGLPPLSDQY
PREELTRIVRNADPIAKYLQKEMQVIRSNPSFNIPTGCLEVFPEAEWSQG
VQGTLRIKKYLTVEQIMTCVADTCRRFFDRGYSPKDVAVLVSTAKEVEHY
KYELLKAMRKKRVVQLSDACDMLGDHIVLDSVRRFSGLERSIVFGIHPRT
ADPAILPNVLICLASRAKQHLYIFPWG
3D structure
PDB7zes Mechanistic understanding of human SLFN11.
ChainA
Resolution3.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A N633 Q634 R674 E676 A816 S853 R856 A873 N561 Q562 R602 E604 A744 S781 R784 A801
BS02 MG A E209 E214 K216 E174 E179 K181
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0002376 immune system process
GO:0006338 chromatin remodeling
GO:0006974 DNA damage response
GO:0008156 negative regulation of DNA replication
GO:0043111 replication fork arrest
GO:0051607 defense response to virus
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005829 cytosol
GO:0090734 site of DNA damage

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zes, PDBe:7zes, PDBj:7zes
PDBsum7zes
PubMed36115853
UniProtQ7Z7L1|SLN11_HUMAN Schlafen family member 11 (Gene Name=SLFN11)

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