Structure of PDB 7zee Chain A

Receptor sequence
>7zeeA (length=282) Species: 9606 (Homo sapiens) [Search protein sequence]
RSMAEEVSTLMKATVLMRQPGRVQEIVGALRKGGGDRLQVISDFDMTLSR
FAYNGKRCPSSYNILDNSKIISEECRKELTALLHHYYPIEIDPHRTVKEK
LPHMVEWWTKAHNLLCQQKIQKFQIAQVVRESNAMLREGYKTFFNTLYHN
NIPLFIFSAGIGDILEEIIRQMKVFHPNIHIVSNYMDFNEDGFLQGFKGQ
LIHTYNKNSSACGKTNVILLGDSIGDLTMADGVPGVQNILKIGFLNDKVE
ERRERYMDSYDIVLEKDETLDVVNGLLQHILC
3D structure
PDB7zee Substrate-Based Design of Cytosolic Nucleotidase IIIB Inhibitors and Structural Insights into Inhibition Mechanism.
ChainA
Resolution1.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.5: 5'-nucleotidase.
3.1.3.91: 7-methylguanosine nucleotidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D41 D43 D230 D43 D45 D222
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005515 protein binding
GO:0008253 5'-nucleotidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0009117 nucleotide metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7zee, PDBe:7zee, PDBj:7zee
PDBsum7zee
PubMed35631380
UniProtQ969T7|5NT3B_HUMAN 7-methylguanosine phosphate-specific 5'-nucleotidase (Gene Name=NT5C3B)

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