Structure of PDB 7zd7 Chain A

Receptor sequence

>7zd7A (length=414) Species: 1148 (Synechocystis sp. PCC 6803)

KYDIKDISLAPQGRQEIEWAAREMPVLKQIRERFAQEKPFAGIRLVACCH
VTTETANLAIALHAGGADSLLIASNPLSTQDDVAACLVADYGIPVYAIKG
EDNETYHRHVQIALDHRPNIIIDDGSDVVATLVQERQHQLSDIIGTTEET
TTGIVRLRAMFNDGVLTFPAMNVNDADTKHFYDNRYGTGQSTLDGIIRAT
NILLAGKTIVVAGYGWCGKGVAMRAKGMGADVIVTEISPVPAIEAAMDGF
RVMPMAEAAHQGDIFITVTGNKHVIRPEHFAVMKDGAIVCNSGHFDIEID
LKSLKEQAKEVKEVRNFTEQYILPNGKSIIVIGEGRLVNLAAATGHPSAV
MDMSFANQALACEHLVKNKGQLEPGMHSIPVEVDQEIARLKLQAMGIAID
SLTPEQVEYINSWA

3D structure

• PDB: 7zd7 Biochemical and structural insights into an unusual, alkali-metal-independent S-adenosyl-L-homocysteine hydrolase from Synechocystis sp. PCC 6803.
• Chain: A
• Resolution: 1.9 Å

Enzymatic activity

• Enzyme Commision number: 3.13.2.1: adenosylhomocysteinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	T158 T159 T160 N192 G221 G223 W224 C225 E244 I245 T277 N279 S300 G301 H302 N347 H354	T150 T151 T152 N184 G213 G215 W216 C217 E236 I237 T269 N271 S292 G293 H294 N339 H346
BS02	ADN	A	H58 T60 E62 D132 E157 T158 K187 D191 H302 L345 H354 M359 F363	H50 T52 E54 D124 E149 T150 K179 D183 H294 L337 H346 M351 F355
BS03	RB	A	T61 Q88	T53 Q80
BS04	RB	A	Y417 S420	Y409 S412

Gene Ontology

Molecular Function

• GO:0004013 adenosylhomocysteinase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0006730 one-carbon metabolic process
• GO:0033353 S-adenosylmethionine cycle
• GO:0071269 L-homocysteine biosynthetic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:7zd7, PDBe:7zd7, PDBj:7zd7
• PDBsum: 7zd7
• PubMed: 35775986
• UniProt: P74008|SAHH_SYNY3 Adenosylhomocysteinase (Gene Name=ahcY)