Structure of PDB 7zcz Chain A

Receptor sequence
>7zczA (length=328) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
YINSKYKIDLDKIMTKMKNKSVINIDDVDDEELLAILYTSKQFEKILKNN
EDSKYLENKVFCSVFLEPSTRTRCSFDAAILKLGSKVLNITDMNSTSFYK
GETVEDAFKILSTYVDGIIYRDPSKKNVDIAVSSSSKPIINAGNGTGEHP
TQSLLDFYTIHNYFPFILDRNINKKLNIAFVGDLKNGRTVHSLSKLLSRY
NVSFNFVSCKSLNIPKDIVNTITYNLKKNNFYSDDSIKYFDNLEEGLEDV
HIIYMTRIQKNAFILSNKTLENTRDDTKILHPLPRVNEIKVEVDSNPKSV
YFTQAENGLYVRMALLYLIFSSTSHPQF
3D structure
PDB7zcz Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials.
ChainA
Resolution2.45 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.3.2: aspartate carbamoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C2B A F136 E140 L149 F98 E102 L111
BS02 C2B A T108 R109 T70 R71
Gene Ontology
Molecular Function
GO:0004070 aspartate carbamoyltransferase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016743 carboxyl- or carbamoyltransferase activity
Biological Process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006520 amino acid metabolic process
GO:0044205 'de novo' UMP biosynthetic process
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7zcz, PDBe:7zcz, PDBj:7zcz
PDBsum7zcz
PubMed36195578
UniProtA0A5K1K910

[Back to BioLiP]