Structure of PDB 7z7c Chain A

Receptor sequence

>7z7cA (length=158) Species: 32630 (synthetic construct) [Search protein sequence]

DLGKKLLEAAVDGQDDEVRILMANGADVNAADWWGLTPLHLAAWHGHLEI
VEVLLKTGADVNASDNNGITPLHLAAARGHLEIVEVLLKAGADVNARDTS
GDTPLHLAAMQGHLEIVEVLLKHGADVNAQDKFGKTPFDLAIDNGNEDIA
EVLQKAAK

3D structure

PDB

7z7c Trapping the HIV-1 V3 loop in a helical conformation enables broad neutralization.

Chain

Resolution

1.22 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	W36 L38 L43 W46 H47 D67 N69 I71 A79 R80 S102 D104 L109 M112 Q113 D133 F135 L142	W34 L36 L41 W44 H45 D65 N67 I69 A77 R78 S100 D102 L107 M110 Q111 D131 F133 L140
BS02	GLY	A	D62 N64 S66	D60 N62 S64

External links

PDB	RCSB:7z7c, PDBe:7z7c, PDBj:7z7c
PDBsum	7z7c
PubMed	37605043

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