Structure of PDB 7z70 Chain A

Receptor sequence
>7z70A (length=575) Species: 9606 (Homo sapiens) [Search protein sequence]
DEAEASKFVEEYDRTSQVVWNEYAGANWNYNTNITTETSKILLQKNMQIA
QHTLKYGTQARKFDVNQLQNTTIKRIIKKVQDLERAALPAQELEEYNKIL
LDMETTYSVATVCHPQGSCLQLEPDLTNVMATSRKYEDLLWAWEGWRDKA
GRAILQFYPKYVELINQAARLNGYVDAGDSWRSMYETPSLEQDLERLFQE
LQPLYLNLHAYVRRALHRHYGAQHINLEGPIPAHLLGNMWAQTWSNIYDL
VVPFPSAPSMDTTEAMLKQGWTPRRMFKEADDFFTSLGLLPVPPEFWQKS
MLEKPTDGREVVCHASAWDFYNGKDFRIKQCTTVNLEDLVVAHHEMGHIQ
YFMQYKDLPVALREGANPGFHEAIGDVLALSVSTPKHLHSLNLLSSSDEH
DINFLMKMALDKIAFIPFSYLVDQWRWRVFDGSITKENYNQEWWSLRLKY
QGLCPPVPRTQGDFDPGAKFHIPSSVPYIRYFVSFIIQFQFHEALCQAAG
HTGPLHKCDIYQSKEAGQRLATAMKLGFSRPWPEAMQLITGQPQMSASAM
LSYFKPLLDWLRTENELHGEKLGWP
3D structure
PDB7z70 Structural basis for the inhibition of human angiotensin-1 converting enzyme by fosinoprilat.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.15.1: peptidyl-dipeptidase A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC A S45 E49 S6 E10
BS02 KS8 A H353 A354 S355 W357 H383 E384 K511 H513 Y520 Y523 H314 A315 S316 W318 H344 E345 K469 H471 Y478 Y481
BS03 ZN A H383 H387 E411 H344 H348 E372
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z70, PDBe:7z70, PDBj:7z70
PDBsum7z70
PubMed35653492
UniProtP12821|ACE_HUMAN Angiotensin-converting enzyme (Gene Name=ACE)

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