Structure of PDB 7z5x Chain A

Receptor sequence
>7z5xA (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
LPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGS
TDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLT
YLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCL
VSVKDYTSPRIVKIGDFLPVRWMAPESLMDGIFTTQSDVWSFGILIWEIL
TLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQR
PTFHRIQDQLQLFRNFFLNS
3D structure
PDB7z5x Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors.
ChainA
Resolution2.035 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AWJ A L1951 V1959 A1978 L2028 M2029 G2032 D2033 L2086 G2101 L15 V23 A42 L92 M93 G96 D97 L150 G165
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7z5x, PDBe:7z5x, PDBj:7z5x
PDBsum7z5x
PubMed35920716
UniProtP08922|ROS1_HUMAN Proto-oncogene tyrosine-protein kinase ROS (Gene Name=ROS1)

[Back to BioLiP]