Structure of PDB 7z5u Chain A

Receptor sequence
>7z5uA (length=386) Species: 1498 (Hathewaya histolytica) [Search protein sequence]
DHDKFLDDAEKHYLPKTYTFDNGTFIIRAGDKVSEEKIKRLYWASREVKS
QFHRVVGNDKALEVGNADDVLTMKIFNSPEEYKFNTTDNGGLYIEPRGTF
YTYERTPQQSIFSLEELFRHEYTHYLQARYLVDGLWGQGPFYEKNRLTWF
DEGTAEFFAGSTRTSGVLPRKLILGYLAKDKVDHRYSLKKTLNSGYDDSD
WMFYNYGFAVAHYLYEKDMPTFIKMNKAILNTDVKSYDEIIKKLSDDANK
NTEYQNHIQELVDKYQGAGIPLVSDDYLKDHGYKKASEVYSEISKAASLT
NTSVTAEKSQYFNTFTLRGTYTGETSKGEFKDWDEMSKKLDGTLESLAKN
SWSGYKTLTAYFTNYRVTSDNKVQYDVVFHGVLTDN
3D structure
PDB7z5u Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.3: microbial collagenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H523 H527 E555 H120 H124 E152
BS02 IFW A N492 G494 Y496 E498 H523 E524 H527 W539 E555 Y599 W604 Y607 N89 G91 Y93 E95 H120 E121 H124 W136 E152 Y196 W201 Y204
BS03 CA A E498 A531 V535 G537 E95 A128 V132 G134
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z5u, PDBe:7z5u, PDBj:7z5u
PDBsum7z5u
PubMed36154055
UniProtQ9X721|COLG_HATHI Collagenase ColG (Gene Name=colG)

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