Structure of PDB 7z4r Chain A

Receptor sequence
>7z4rA (length=494) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
AGASMQSAANITLRQILEPNNVNLRSKKTHIVCTLGPACKSVETLVKLID
AGMDICRFNFSHGSHEDHKEMFNNVLKAQELRPNCLLGMLLDTKGPEIRT
GFLKNKEVHLKEGSKLKLVTDYEFLGDETCIACSYKKLPQSVKPGNIILI
ADGSVSCKVLETHEDHVITEVLNSAVIGERKNMNLPNVKVDLPIISEKDK
NDILNFAIPMGCNFIAASFIQSADDVRLIRNLLGPRGRHIKIIPKIENIE
GIIHFDKILAESDGIMIARGDLGMEISPEKVFLAQKLMISKCNLQGKPII
TATQMLESMTKNPRPTRAEVTDVANAVLDGTDAVMLSGETAGGKFPVEAV
TIMSKICLEAEACIDYKLLYQSLVNAIETPISVQEAVARSAVETAESIQA
SLIIALTETGYTARLIAKYKPSCTILALSASDSTVKCLNVHRGVTCIKVG
SFQGTDIVIRNAIEIAKQRNMAKVGDSVIAIHGTNLMKVVQIEL
3D structure
PDB7z4r Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E257 D281 E247 D271
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z4r, PDBe:7z4r, PDBj:7z4r
PDBsum7z4r
PubMed35998635
UniProtC6KTA4

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