Structure of PDB 7z4m Chain A

Receptor sequence
>7z4mA (length=497) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
AAGASMQSAANITLRQILEPNNVNLRSKKTHIVCTLGPACKSVETLVKLI
DAGMDICRFNFSHGSHEDHKEMFNNVLKAQELRPNCLLGMLLDTKGPEIR
TGFLKNKEVHLKEGSKLKLVTDYEFLGDETCIACSYKKLPQSVKPGNIIL
IADGSVSCKVLETHEDHVITEVLNSAVIGERKNMNLPNVKVDLPIISEKD
KNDILNFAIPMGCNFIAASFIQSADDVRLIRNLLGPRGRHIKIIPKIENI
EGIIHFDKILAESDGIMIARGDLGMEISPEKVFLAQKLMISKCNLQGKPI
ITATQMLESMTKNPRPTRAEVTDVANAVLDGTDCVMLSGETAGGKFPVEA
VTIMSKICLEAEACIDYKLLYQSLVNAIETPISVQEAVARSAVETAESIQ
ASLIIALTETGYTARLIAKYKPSCTILALSASDSTVKCLNVHRGVTCIKV
GSFQGTDIVIRNAIEIAKQRNMAKVGDSVIAIHGIGTNLMKVVQIEL
3D structure
PDB7z4m Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.40: pyruvate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A E257 D281 E248 D272
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0030955 potassium ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0051289 protein homotetramerization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z4m, PDBe:7z4m, PDBj:7z4m
PDBsum7z4m
PubMed35998635
UniProtC6KTA4

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