Structure of PDB 7z3j Chain A

Receptor sequence
>7z3jA (length=1119) Species: 10116 (Rattus norvegicus) [Search protein sequence]
QAEVLHLCRSLEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADK
IEGSIDIREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLK
TLSLQATSEDEVNMWIKGLTWLMEDTLQAATPLQIERWLRKQFYSVDRNR
EDRISAKDLKNMLSQVNYRVPNMRDITYGQFAQLYRSLMYSAQKTMDLPF
LELCQVSLSEFQQFLLEYQGELWAVDRLQVQEFMLSFLRDPLREIEEPYF
FLDELVTFLFSKENSVWNSQLDAVCPETMNNPLSHYWISSSHNTYLTGDQ
FSSESSLEAYARCLRMGCRCIELDCWDGPDGMPVIYHGHTLTTKIKFSDV
LHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQHFRKVLGDTLLTKPVD
IAADGLPSPNQLKRKILIKHKKLAEGSAYEEVPTSVMYSENDISNSIKNG
ILYLEDPVNHEWYPHYFVLTSSKIYYSEETSLHSSEKWFHGKLGAGRDGR
HIAERLLTEYCIETGAPDGSFLVRESETFVGDYTLSFWRNGKVQHCRIHS
RQDAGTPKFFLTDNLVFDSLYDLITHYQQVPLRCNEFEMRLSEPVPQTNA
HESKEWYHASLTRAQAEHMLMRVPRDGAFLVRKRNEPNSYAISFRAEGKI
KHCRVQQEGQTVMLGNSEFDSLVDLISYYEKHPLYRKMKLRYPINEEALE
KIGSGSTFKCAVKALFDYKAQREDELTFTKSAIIQNVEKQDGGWWRGDYG
GKKQLWFPSNYVEEMINPAILEPEREHLDENSPLGDLLRGVLDVPACQIA
IRPEGKNNRLFVFSISMPSVAQWSLDVAADSQEELQDWVKKIREVAQTAD
KKIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAK
GKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP
MQMNQALFMAGGHCGYVLQPSTMRDEAFDPFDKSSLRGLEPCVICIEVLG
ARHLPKNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFH
FQISNPEFAFLRFVVYEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNY
SEDLELASLLIKIDIFPAK
3D structure
PDB7z3j Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.11: phosphoinositide phospholipase C.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A N336 E365 D367 E414 N293 E322 D324 E371
BS02 CA A E351 R355 E308 R312
BS03 I3P A H335 N336 E365 H380 E414 K462 S982 R1010 Y1012 H292 N293 E322 H337 E371 K419 S886 R914 Y916
Gene Ontology
Molecular Function
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0005509 calcium ion binding
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0007165 signal transduction
GO:0009395 phospholipid catabolic process
GO:0035556 intracellular signal transduction

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7z3j, PDBe:7z3j, PDBj:7z3j
PDBsum7z3j
PubMed35749497
UniProtP10686|PLCG1_RAT 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (Gene Name=Plcg1)

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