Structure of PDB 7z2h Chain A

Receptor sequence
>7z2hA (length=526) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence]
SPIETVPVKLKPGMDGPKVKQWPLTEALVEICTEMEKEGKISKIGPENPY
NTPVFACKKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDA
YFSVPLDEDFRKYTAFTIPIRYQYNVLPQGWKGSPAIFQSSMTKILEPFK
KQNPDIVIYQYIDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQ
KEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYP
GIKVRQLSKLLRGTLTEVIPLTEEAELELAENREILKEPVHGVYYDPSKD
LIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVKQLTEAVQK
ITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTPPLVK
LWYQLEKEPIVGAETFYVDGAANRELGKAGYVTNKGRQKVVPLTNTTNQK
TELQAIYLALQDSGLEVNIVTNSQYALGIIQAQPDKSESELVNQIIEQLI
KKEKVYLAWVPAHKGIGGNEQVDKLV
3D structure
PDB7z2h Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine.
ChainA
Resolution3.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7z2h, PDBe:7z2h, PDBj:7z2h
PDBsum7z2h
PubMed35858448
UniProtP03366|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)

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