Structure of PDB 7z0h Chain A

Receptor sequence
>7z0hA (length=1419) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KEVVVSETPKRIKGLEFSALSAADIVAQSEVEVSTRDLFDLEKDRAPKAN
GALDPKMGVSSSSLECATCHGNLASCHGHFGHLKLALPVFHIGYFKATIQ
ILQGICKNCSAILLSETDKRQFLHELRRPGVDNLRRMGILKKILDQCKKQ
RRCLHCGALNGVVKKAAALKIIHDTFRWVGKKSAPEKDIWVGEWKEVLAH
NPELERYVKRCMDDLNPLKTLNLFKQIKSADCELLGIDATVPSGRPETYI
WRYLPAPPVCIRPSVMMQDSPASNEDDLTVKLTEIVWTSSLIKAGLDKGI
SINNMMEHWDYLQLTVAMYINSDSVKPIRGFCQRLKGKQGRFRGNLSGKR
VDFSGRTVISPDPNLSIDEVAVPDRVAKVLTYPEKVTRYNRHKLQELIVN
GPNVHPGANYLLKRNEDARRNLRYGDRMKLAKNLQIGDVVERHLEDGDVV
LFNRQPSLHRLSILSHYAKIRPWRTFRLNECVCTPYNADFDGDEMNLHVP
QTEEARAEAINLMGVKNNLLTPKSGEPIIAATQDFITGSYLISHKDSFYD
RATLTQLLSMMSDGIEHFDIPPPAIMKPYYLWTGKQVFSLLIKPNHNSPV
VINLDAKNKVFVPPKSKSLPNEMSQNDGFVIIRGSQILSGVMDKSVLGDG
KKHSVFYTILRDYGPQEAANAMNRMAKLCARFLGNRGFSIGINDVTPADD
LKQKKEELVEIAYHKCDELITLFNKGELETQPGCNEEQTLEAKIGGLLSK
VREEVGDVCINELDNWNAPLIMATCGSKGSTLNVSQMVAVVGQQIISGNR
VPDGFQDRSLPHFPKNSKTPQSKGFVRNSFFSGLSPPEFLFHAISGREGL
VDTAVKTAETGYMSRRLMKSLEDLSCQYDNTVRTSANGIVQFTYGGDGLD
PLEMEGNAQPVNFNRSWDHAYNITFNNQDKGLLPYAIMETANEILGPLEE
RLVRYDNSGCLVKREDLNKAEYVDQYDAERDFYHSLREYINGKATALANL
RKSRGMLGLLEPPAKELQGIDPDETVPDNVKTSVSQLYRISEKSVRKFLE
IALFKYRKARLEPGTAIGAIGAQSIGEPGTQMTLKTFHFAGVASMNVTLG
VPRIKEIINASKVISTPIINAVLVNDNDERAARVVKGRVEKTLLSDVAFY
VQDVYKDNLSFIQVRIDLGTIDKLQLELTIEDIAVAITRASKLKIQASDV
NIIGKDRIAINVFPSENDVFYRMQQLRRALPDVVVKGLPDISRAVINIRD
DGKRELLVEGYGLRDVMCTDGVIGSRTTTNHVLEVFSVLGIEAARYSIIR
EINYTMSNHGMSVDPRHIQLLGDVMTYKGEVLGITRFGLSKMRDSVLQLA
SFEKTTDHLFDAAFYMKKDAVEGVSECIILGQTMSIGTGSFKVVKGTNIS
EKDLVPKRCLFESLSNEAA
3D structure
PDB7z0h Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C67 C77 H80 C66 C76 H79
BS02 ZN A C107 C154 C157 C106 C153 C156
BS03 MG A D511 D513 D515 D489 D491 D493
BS04 MG A D511 D513 D489 D491
Gene Ontology
Molecular Function
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006383 transcription by RNA polymerase III
GO:0006384 transcription initiation at RNA polymerase III promoter
GO:0006386 termination of RNA polymerase III transcription
GO:0042797 tRNA transcription by RNA polymerase III
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005666 RNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7z0h, PDBe:7z0h, PDBj:7z0h
PDBsum7z0h
PubMed36977686
UniProtP04051|RPC1_YEAST DNA-directed RNA polymerase III subunit RPC1 (Gene Name=RPO31)

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